Expect a Gender-Blender Name, lots of Gender-Neutral Writing and Pronoun Trouble.
Gender and internet dating
Most have 14 or 15-year-old daughters who are smart, quirky, and struggling socially. And they are often asking for medical interventions – hormones and surgery – that may render them sterile, affect their liver, or lead to high blood pressure, among other possible side effects.
The parents are bewildered and terrified, careful to let me know that they love their child and would support any interventions that were truly necessary.
Contrast with Transsexual and Hermaphrodite, which are real-life phenomena (though on rare occasions, a Gender Bender character might a hermaphrodite instead of, strictly speaking, the "opposite sex"; also, Gender Bender stories can intersect with transsexual characters, by having someone transition unexpectedly by magic, or have the experience of being gender-changed bring a transsexual character out of denial.
Not to mention all the possibilities of using Gender Bender stories as metaphors for transsexuality...).
But sometimes all I can do is stand helpless and witness the wreckage. Like many of the young people I hear about, Claire’s daughter Molly had had a series of complex medical and psychological challenges as an adolescent.
Though profoundly gifted, the teenager struggled with autism, dyspraxia, and anxiety, all of which made school challenging.
If a man and a woman bodies, it's a variant of "Freaky Friday" Flip.
Male-to-female transformations tend to vastly outnumber the opposite when this trope is in play. It might be Played for Laughs, Played for Drama, or even played for horror if Loss of Identity or an unusual amount of Squick is involved.
For Laws related to this trope, see the First Law of Gender-Bending, the Second Law of Gender Bending, and the Third Law of Gender Bending.
Man, I Feel Like a Woman, Different for Girls, and Attractive Bent-Gender are also common enough that they approach the level of Law.
Also contrast with Easy Sex Change, which deals with idealized but realistic takes on the Transsexual experience. If the character belongs to a species that does this as regular thing, see Sex Shifter.